Muscle loss on GLP-1s — how much is real?

2026-08-06 36 views 3 posts

There's been a lot of discussion about GLP-1s causing muscle loss. The data shows ~25-40% of weight lost is lean mass. Is this specific to GLP-1s or just a consequence of any rapid weight loss? How are you all preserving muscle?

My doctor said the muscle loss is proportional to weight loss rate, not specific to GLP-1s. The fix is the same as any cut: high protein (1g/lb), resistance training 3-4x/week, and don't lose faster than 1-2 lbs/week.

Lost 45 lbs on Mounjaro while actually gaining muscle mass (DEXA scan confirmed). 200g protein/day, 5x/week strength training. It's doable if you're disciplined.