The CagriSema combination (cagrilintide + semaglutide) just showed 25% weight loss in Phase 2. That's approaching bariatric surgery territory. Cagrilintide is an amylin analog that complements GLP-1. Anyone following this combo? It could be the next big thing after retatrutide.
Cagrilintide + semaglutide (CagriSema) — 25% weight loss in trials
Amylin + GLP-1 is a logical combo — amylin suppresses glucagon and slows gastric emptying through a different pathway. The synergistic effect makes sense mechanistically. Novo is positioning this as their answer to retatrutide.
Totally agree. I was on metformin for years and it did nothing for weight. GLP-1 was a game changer. It's a tool, not cheating.
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