Retatrutide Dosage Calculator
Calculate your retatrutide research dosage, titration schedule, and reconstitution syringe draw volume. Based on published Phase 2 clinical trial data.
Titration Schedule
Enter your current week to see the recommended retatrutide dose based on the Phase 2 clinical trial protocol.
Recommended Dose
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Retatrutide Dosage Chart
| Week | Dose | Phase | Notes |
|---|---|---|---|
| 1–4 | 2 mg / week | Initiation | Starting dose to assess tolerance |
| 5–8 | 4 mg / week | Titration 1 | First dose escalation |
| 9–12 | 8 mg / week | Titration 2 | Second dose escalation |
| 13+ | 12 mg / week | Target dose | Maximum recommended research dose |
Clinical Trial Results
| Dose Group | Weight Loss | % Lost ≥5% | % Lost ≥10% |
|---|---|---|---|
| 1 mg/weekly | -8.7% | 74% | 33% |
| 4 mg/weekly | -17.1% | 91% | 67% |
| 8 mg/weekly | -22.8% | 100% | 88% |
| 12 mg/weekly | -24.2% | 100% | 93% |
Important Notes
- Administered once weekly via subcutaneous injection
- Can be administered at any time of day, with or without meals
- Dose must be increased gradually to minimize side effects
- Maximum recommended dose: 12 mg/week
- If a dose is missed, administer within 5 days or skip and resume schedule
- Most common side effects: nausea (45%), vomiting (19%), constipation (16%), diarrhea (15%)
- Contraindications: pregnancy, lactation, history of thyroid cancer
Reconstitution Calculator
Calculate how much bacteriostatic water to add and how many units to draw on your syringe for your retatrutide dose.
Results
Enter values and click Calculate
How Reconstitution Works
- Determine concentration: Divide peptide amount by water volume (e.g., 5 mg ÷ 2 mL = 2.5 mg/mL)
- Calculate draw volume: Divide your dose by concentration (e.g., 2 mg ÷ 2.5 mg/mL = 0.8 mL)
- Convert to syringe units: Multiply mL by 100 for U-100 syringes (0.8 mL = 80U)
- Verify syringe capacity: Ensure the draw volume fits your syringe
Example Calculation
Vial: 5 mg retatrutide
Water: 2 mL bacteriostatic
Dose: 2 mg
Syringe: 100U (1 mL)
Concentration: 5 mg ÷ 2 mL = 2.5 mg/mL
Draw volume: 2 mg ÷ 2.5 mg/mL = 0.8 mL = 80U on a U-100 syringe