Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity

Abstract

Heptapeptide Semax, encompassing the sequence 4-7 of N-terminal domain of the adrenocorticotropic hormone (ACTH) and a C-terminal Pro-Gly-Pro tripeptide, belongs to a short regulatory peptides family.. This compound has been found to affect learning processes and to exert marked neuroprotective activities on cognitive brain functions.. Dys-homeostasis of metal ions is involved in several.

Hallazgos Clave

Dys-homeostasis of metal ions is involved in several neurodegenerative disorders and growing evidences have showed that brain is a specialized organ able to concentrate metal ions. | The equilibrium study clearly demonstrated the presence of three complex species.

Diseño del Estudio

Research study