The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism
Autores: Lu Z, Ngan MP, Liu JYH, Yang L, Tu L, et al.
Ghrelin mimetics anamorelin and ipamorelin alleviated cisplatin-induced weight loss in ferrets; anamorelin also exhibited anti-emetic effects via central mechanisms.
Abstract
This study investigated whether ghrelin mimetics, namely anamorelin and ipamorelin, can alleviate weight loss and inhibition of feeding observed during acute and delayed phases of cisplatin-induced emesis in ferrets.. The potential of anamorelin to inhibit electrical field stimulation (EFS)-induced contractions of isolated ferret ileum was compared with ipamorelin.. In other experiments, ferrets.
Hallazgos Clave
The potential of anamorelin to inhibit electrical field stimulation (EFS)-induced contractions of isolated ferret ileum was compared with ipamorelin. | The effect of anamorelin (10 µg) was also assessed following intracerebroventricular aDiseño del Estudio
Research studyMore Ipamorelin Research Papers
Additional peer-reviewed studies and clinical trials indexed for Ipamorelin on PepsReview:
- Ipamorelin, the first selective growth hormone secretagogue — Eur J Endocrinol, 1998 (560 citations)
- Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats — Growth Horm IGF Res, 1999 (540 citations)
- Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers — Pharm Res, 1999 (540 citations)
- Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin — Bioorg Med Chem Lett, 2001 (500 citations)
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About This Ipamorelin Research Paper
This study is part of PepsReview's indexed research library for Ipamorelin. We systematically index peer-reviewed publications, clinical trial results, and scientific studies related to Ipamorelin to provide researchers and clinicians with a centralized, searchable database of evidence. Each paper in our index includes metadata such as journal name, publication year, citation count, study type, and condition studied, along with key findings and study design summaries where available.
Ipamorelin is classified in our Growth hormone boosters category. Selective GHRP — releases growth hormone without hunger side effects For a complete list of research papers on Ipamorelin, visit the research index page. To compare vendor pricing and read user reviews, visit the main Ipamorelin profile page.
Understanding Ipamorelin Research
Ipamorelin has been the subject of growing scientific interest, with researchers investigating its pharmacological properties, therapeutic potential, and safety profile across multiple study designs. The research landscape for Ipamorelin includes preclinical in vitro and animal model studies that elucidate its mechanism of action, Phase I clinical trials assessing safety and pharmacokinetics in human subjects, and larger Phase II and Phase III trials evaluating efficacy in target populations. Published studies vary in design — some are randomized controlled trials with placebo groups, others are open-label dose-escalation studies, and many are retrospective analyses of real-world data from clinics and compounding pharmacies.
When interpreting Ipamorelin research, it is important to consider several factors: the study population size and demographics, the dosage range tested, the duration of follow-up, the presence of confounding variables, and whether the results have been replicated in independent cohorts. Single studies, even well-designed ones, should not be considered definitive evidence. The strongest conclusions come from meta-analyses that pool data across multiple studies and from replicated findings across different research groups. Our research index for Ipamorelin allows you to browse all available studies in one place and compare their methodologies, outcomes, and limitations side by side.
How to Evaluate Peptide Research Quality
Not all published studies carry equal weight. When reviewing Ipamorelin research, consider the following quality indicators: peer-reviewed publication in a reputable journal with an impact factor, large sample sizes (n > 100 for clinical studies), randomized and blinded study designs, clearly defined endpoints, appropriate control groups, and disclosure of funding sources and potential conflicts of interest. Studies published in top-tier journals such as the New England Journal of Medicine, The Lancet, JAMA, or Diabetes Care undergo rigorous peer review and are generally more reliable. Preclinical studies and animal models, while valuable for hypothesis generation, should not be extrapolated to human use without clinical validation.
Additionally, pay attention to the condition studied and whether it aligns with your research interest. A study examining Ipamorelin for one condition may not be applicable to a different therapeutic context. Dosage ranges, administration routes, and treatment durations can significantly affect outcomes. Always cross-reference findings with the broader literature and consult the full text of the original publication rather than relying solely on abstracts or summaries.
Related Research on Ipamorelin
PepsReview continues to index new Ipamorelin publications as they appear in the scientific literature. Our research library is updated regularly with studies from PubMed, ClinicalTrials.gov, and direct journal submissions. If you are aware of a published study that is not yet in our index, you can contact our editorial team to request its inclusion. We also welcome submissions of conference abstracts, preprint articles, and independent lab reports that meet our quality criteria.
For researchers new to Ipamorelin, we recommend starting with the most highly cited papers in our index, as these typically represent foundational studies that have shaped the field. You can also browse by study type — clinical trials, animal studies, review articles, or case reports — to find the evidence most relevant to your work.
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