Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined

After 8-week low-calorie diet, liraglutide plus exercise maintained weight loss best over 1 year compared to either intervention alone in adults with obesity.

Abstract

Weight regain after weight loss is a major problem in the treatment of persons with obesity.. In a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of the height in meters], 32 to 43) who did not have diabetes.. After an 8-week low-calorie diet, participants were randomly assigned for 1 year to one.

Key Findings

In a randomized, head-to-head, placebo-controlled trial, we enrolled adults with obesity (body-mass index [the weight in kilograms divided by the square of the height in meters], 32 to 43) who did not... | After an 8-week low-calorie diet, participants were randomly assigned for 1 year to one of four strategies: a moderate-to-vigorous-intensity exercise program plus placebo (exercise group); treatment w... | End points with prespecified hypotheses were the change

Study Design

Randomized controlled trial