Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

Phase 3b head-to-head trial comparing tirzepatide vs semaglutide for weight reduction in adults with obesity without type 2 diabetes.

Abstract

Tirzepatide and semaglutide are highly effective medications for obesity management.. The efficacy and safety of tirzepatide as compared with semaglutide in adults with obesity but without type 2 diabetes is unknown.. In this phase 3b, open-label, controlled trial, adult participants with obesity but without type 2 diabetes were randomly assigned in a 1:1 ratio to receive the maximum tolerated.

Key Findings

Tirzepatide and semaglutide are highly effective medications for obesity management. | The efficacy and safety of tirzepatide as compared with semaglutide in adults with obesity but without type 2 diabetes is unknown. | Key secondary end points included weight reductions of at least 10%, 15%, 20%, and 25% and a change in waist circumference from base

Study Design

Randomized controlled trial