alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells

Abstract

alpha-MSH signals by binding to the melanocortin-1 receptor (MC-1R) and elevating cyclic AMP in several different cells.. The anti-inflammatory properties of this peptide are also believed to be cyclic AMP dependent.. The carboxyl terminal tripeptides of alpha-MSH (KPV / KP-D-V) are the smallest minimal sequences reported to prevent inflammation but it is not known if they operate via MC-1R or.

Hallazgos Clave

The aim of this study was to examine the intracellular signalling of key MSH and ACTH peptides in human keratinotocytes. | No elevation in cyclic AMP was detected in either HaCaT or normal human keratinocytes in response to alpha-MSH, KPV or ACTH peptides. | Rapid and acute intracellular calcium, however, were observed in HaCaT keratinocytes in

Diseño del Estudio

Research study