Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells

Abstract

A splice form of IGF-1, IGF-1Eb, is upregulated after exercise or injury.. Physiological responses have been ascribed to the 24-amino acid COOH-terminal peptide that is cleaved from the NH3-terminal 70-amino acid mature IGF-1 protein.. This COOH-terminal peptide was termed "mechano-growth factor" (MGF).

Hallazgos Clave

As such, MGF could represent a promising strategy to improve muscle regeneration. | Thus, at our two pharmaceutical companies, we attempted to reproduce the claimed effect of MGF peptides on human and mouse muscle myoblast proliferation and differentiation in vitro.

Diseño del Estudio

In vitro study