Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells

Abstract

A splice form of IGF-1, IGF-1Eb, is upregulated after exercise or injury.. Physiological responses have been ascribed to the 24-amino acid COOH-terminal peptide that is cleaved from the NH3-terminal 70-amino acid mature IGF-1 protein.. This COOH-terminal peptide was termed "mechano-growth factor" (MGF).

Key Findings

As such, MGF could represent a promising strategy to improve muscle regeneration. | Thus, at our two pharmaceutical companies, we attempted to reproduce the claimed effect of MGF peptides on human and mouse muscle myoblast proliferation and differentiation in vitro.

Study Design

In vitro study