Investigational/Trial Medications

Discuss investigational GLP-1 drugs: retatrutide, cagrilintide, tesofensine, survodutide, mazdutide, orforglipron. Trial results and research.

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Retatrutide

Retatrutide — the triple agonist. Phase 2/3 trial results, sourcing, testing, and comparison with tirzepatide.

127 threads 1320 messages
Latest:
The mirror caught a new angle by my hip bones
by Kevin_J 2026-10-07
Cagrilintide

Cagrilintide and CagriSema — dual therapy with semaglutide. Trial results, weight loss data, and sourcing discussion.

3 threads 51 messages
Latest:
Cagrilintide trial puzzle: 609, 300, 178, and 3400
by paige_clark 2026-10-06
Tesofensine

Tesofensine — the forgotten weight loss drug. Mechanism, trial results, sourcing, and user experiences.

3 threads 65 messages
Survodutide

Survodutide — dual GLP-1/glucagon agonist. Phase 3 results, MASH data, weight loss, and sourcing.

2 threads 32 messages
Mazdutide

Mazdutide — China's GLP-1/glucagon agonist. Trial data, comparison with survodutide, and availability.

2 threads 42 messages
Orforglipron

Orforglipron — the first oral non-peptide GLP-1. Trial results, dosing, and comparison with injectable GLP-1s.

4 threads 63 messages