Week 14: fasting glucose up while weight down—anyone else?

Fasting glucose can drift if you're eating way less and sleeping bad. Mine went 92 to 101 around week 10, then back to 95 by week 16. CGM showed dawn spikes, not the semaglutide itself.

Anyone mess with protein or workout timing and seen the 6-8am dawn spike move at all? That window seems locked in no matter what.

Mine did opposite. Fasting dropped first, weight lagged till week 8.

NCT06897475's listing says 200 enrolled. Not much gets shared beyond that, but the fasting glucose logs are definitely part of the routine — feels like a lot of tracking for a trial that stays this quiet.

Are they doing CGM or just fingersticks? I'm curious how often they pull A1c.

Worth knowing before you compare anything: the monitoring side of it is just fingersticks and one lab draw. And that 200 is total planned enrollment, not everyone dosed yet.

I've seen the 62-enrolled study too. That's tiny. Hard to draw conclusions from small n.

Small n doesn't mean useless, but I wouldn't compare across trials with different designs.

My fasting glucose rose for a few weeks when I was basically under-eating. Once I added a real dinner and slept seven hours, it came down. Not saying that's what's happening to you, just that weight loss and glucose don't always move together. I also noticed the 62-enrolled NCT07401992 and the 140 in NCT06989203 are still recruiting, so any early forum comparisons are going to be messy. The 609-enrolled NCT07011667 is the one I'd watch if it posts data. What did your overnight CGM look like before the fasting draw?

Under-eatin gmade mine worse too. I thought lower calories = lower fasting, but no.

Protein at 70g while lifting 3x? That's low.

I'm waiting for my next labs before changing anything. Trends beat single readings.

Mine did the same dumb thing around week 12 and it had almost nothing to do with the weight coming off. I was sleeping about 5.5 hours, lifting at 8pm, and eating dinner at 9:15 because my appetite didn't show up until evening — fasting went 91 to 103 over about three weeks. My post-meal numbers got better at the exact same time, which felt completely backwards. What pulled the morning number back down was boring stuff: dinner by 7, lifting before 5pm, closer to 100oz of water, and testing at the same 10 minutes after waking instead of whenever I rolled out of bed. It drifted back to 93-96 by week 21. Worth knowing whether that 104 was a one-off lab draw or your usual routine, because a 6am draw after a late workout and bad sleep is a different animal than a normal Tuesday.

My fasting number is always the last one to get the memo. Scale drops, waist shrinks, glucose just sits there jdging me.

I'll be the disagreeable one: my fasting glucose got worse when I was eating the least. Weeks 8 through 15 I was probably under 1400 calories most days and my morning number hung out between 100 and 106 the whole time, even while I was dropping about a pound a week. Less food in means less glycogen, so your liver just tops you up overnight and the morning read looks higher. Mine started coming down once I added a real carb serving at dinner and stopped doing fasted cardio at 6am. Also, eating way less usually means drinking way less — I was lucky to hit 50oz of water and I'm sure that didn't help. A1c is a 3-month average, so it lags whatever you changed in the last six weeks; I'd watch the 4-week trend instead of one number.

My morning number tracks my sep count harder than anything else — 8k+ days and I'm low 90s, under 4k and I'm 100+. Are you walking on rest days? That was my gap. Lifting three times a week did nothing for my fasting, but 25 minutes after dinner dropped it 6-8 points.

16 weeks of logging seems to be the magic number for this realization. Common surprise: fasting barely budges — 98 to 103, basically flat — while the 2-hour post-dinner number drops from the 150s to the 120s. Nobody warns you that's the one that actually moves. The part people forget is that the morning stick can end up being the least useful number in the whole log, since it's the after-meal reading doing all the talking. Worth knowing before comparing options or deciding whether anything's working. So what do your after-meal readings look like?

Mine turned out to be dinner timing. Eating at 8:30pm versus 6:30pm, roughly the same food, and my morning number ran 7-8 points higher on the late nights. Took me a solid month of CGM data to see it because I kept blaming the food itself. Worth jotting down yur last bite time for a week, it's a cheap experiment.

Adding a non-scale angle: my jeans went from tight in the thigh to genuinely loose a good two weeks before the scale moved at all, and during that same stretch my morning number looked terrible. Sodium and water seem to swing that reading way more than actual fat loss does week to week. Do you have a waist or jeans checkpoint, or is it scale plus labs only?

Sleep is my sleeper variable, pun intended. Two nights under 6 hours and my morning reading jumps 8-10 points like clockwork, then settles by day three. Week 14 is also about when the novelty adrenaline fades and normal life strss creeps back in, which could explain the timing. Did your sleep or work stress change in the last month or so?

My fasting bounced 11 points just from swapping meters, so now I log a 3-day average instead of panicking over one number.

Tracking habit that helped me: I compared weekday vs weekend CGM, and my Monday fasting was 104-108 while Tue-Fri sat 94-99 for about six weeks. I assumed Friday takeout, but the actual reversal was that my step count fell from 8k to 2k on Sat/Sun and I skipped my usual morning walk. Adding two 20-minute walks, one Sat and one Sun, plus a 16oz water before coffee, got my Monday number to 99-101 by week 18. Weight kept dropping the whole time. The other weird bit: my A1c lagged about eight weeks behind those daily swings. Not claiming it's universal, just that my tracker made weekends look innocent when they weren't.

My CGM says stress moves mine more than carbs: deadline week 107, vacation week 93, same meals.

I thought lifting would only help, but my hardest leg day gave the worst next-morning number: 106 after squats vs 97 on rest days. Moving sessions from 7pm to 11am cut that gap to 2-4 points by week 17, though my weight was dropping either way. So the order of changes matters more than one fasting reading.

Three years in and fasting glucose is usually the last number to cooperate. Mine bumped around month 3–4, then settled once my sleep got boringly consistent—my tracker showed fragmented-sleep nights running 8–10 points higher even with the same dinner. What helped was reviewing overnight average and 24h time-in-range instead of the wake-up number. Are you logging sleep and dinner timing alongside it? There was a long “fasting is a lagging indicator” thread here last spring that stopped me over-reading single mornings.

Not a clinician, but I stopped judging my fasting number by the single morning value. The overnight CGM shape was the tell: mine was flat 100–105, then a slow 4–6am rise, more dawn-ish than a middle-of-night crash. Also my fasting reads 5–7 points higher at an 8h fast vs 12h, and later dinners nudged it. In the trials I’ve read, fasting glucose can lag weight loss and be noisy. Are you seeing a dip-then-rise overnight, or just a flat elevated line? That distinction changed how I read my own labs.

Travel-heavy here too. The thing that moved my fasting CGM wasn’t carbs—it was the 5am airport-coffee-plus-no-dinner combo. When I started keeping a hotel-fridge dinner (rotisserie chicken, bagged salad, hummus) and eating before 8pm, my morning line got boring again. Also my A1c lagged my weight by about six weeks. Curious: does your bump show up more on travel weeks or home weeks? And are you spreading that 70g protein across the day or mostly one big hit? 70g with lifting 3x would leave me ravenous by 9pm.

Same phase for me: weight down, fasting up, then it drifted back around week 20. Biggest hidden variable was sleep debt, not lifting. Under 6h = +7–9 mg/dL; 7.5h+ = baseline. Also check measurement time: my “fasting” was sometimes 45–90 min after waking, and that alone moved it 8–10 points. Are you anchoring the draw to same wake time and sleep duration, or is the trend mixing those in? That’s the first thing I’d isolate before chasing dawn phenomenon.

Similar arc here: weeks 10–13, down 19 lb, fasting 95→103. My spreadsheet’s top correlation wasn’t training—it was hours between last bite and wake. r=0.61 over 38 days. On 12h+ gaps my 7-day avg was ~6 mg/dL lower than on 9–10h gaps; sleep efficiency added a smaller bump. I also saw one-off 107s after salty late dinners, then 96s next day. Not saying it’s causal, just my n=1. Are you logging last-food-to-wake interval or just the morning number? That gap might separate dawn phenomenon from “still digesting/under-slept” noise better than weekday vs weekend alone.

Not sure if this helps, but I’ve been watching the overnight curve, not just the wake-up number. For me, fasting crept up around week 12–15 even while losing. What helped me see the pattern was checking 3am: mine dips then rises before dawn, so it looked like dawn phenomenon. On nights I eat dinner after 8 or sleep poorly, the whole overnight line is higher, and the morning number follows. Are you able to see a 3am-ish value, or just the fasting reading? That’s what finally made my CGM data less scary.

Separate dawn phenomenon from sleep disruption. My fasting drifted 94→104 around week 13 despite weight loss; CGM showed flat 1–4am, then a 5–7am cortisol-shaped rise. My worst mornings tracked with 3am wakeups, elevated resting HR, and lower sleep efficiency—not carbs. If you have overnight SpO2/HR or wearable data, look at the 2–4am window. A1c can lag; fasting is a single noisy snapshot. What’s your CGM doing 2–4am? That tells you whether it’s hepatic glucose output or fragmented sleep.

I log fasting glucose next to sleep, last meal time, and CGM at 3am vs wake. My 100+ readings were almost all short sleep + late dinner, not lifting. My dawn pattern: 3am ~88, wake ~102. If 3am is already ~100, it’s probably not dawn. Also check actual fasting duration—12h vs 8h moves mine 5–8 points. What’s your 3am-to-wake delta and last meal timing?

Sleep timing messes with my numbers more than anything I eat. Newborn in the house, so "morning" is whatever hour I finally get a stretch — up at 3 to feed the baby, test at 6:30, 104. Same food the day before, same evening walk, doesn't matter.

Since starting a GLP-1, my CGM notes kept calling my fasting number a liar for weeks. I teach middle school band, so concert nights mean picking at leftover cookies in the staff lounge. Carbs weren't the issue; the clock was. I began logging my last bite in the CGM app. Same dinner, two last-bite times: after 9 p.m. put next-morning fasting 8–12 points above finishing by 7. Those end-of-day tastes counted too. Compare last-bite time and sleep, not just weekday/weekend. Anyone else see a shift when lifting time moved? Mine did when I pushed workouts later.

I track weekly averages, and my fasting glucose nudged up around weeks 12–15 too, but the pattern was tied to lifting recovery. Mornings after a heavy lower-body session were 6–10 points higher on my CGM, then settled by the next rest day. Moving that session earlier and keeping my evening meal a bit earlier helped my own averages. Have you compared your fasting numbers on lifting days versus rest days? That comparison was the most useful

Honestly, Empty-nester here, also logging a CGM. My fasting number ran higher on mornings after a hard lifting day or a later-than-usual dinner—not after carbs. I started writing workout, dinner time, and water next to the reading, and the “bump” looked more like a recovery/daytime pattern than a scary trend. Did yours line up with the weeks you were losing fastest or adding lifting volume? I’m trying to separate real changes from ordinary life noise before I worry.

cafe owner here, so the constant taste-testing is my weakness too. Mine bumped when I added heavier lifting, and my CGM showed a dip around 3am then a climb from 4–7am—dawn-ish pattern. My post-meal numbers actually looked better, which confused me. What helped me understand it was logging every cafe bite, even a spoon of ganache, plus how late my last real food was. Did your overnight curve look flat-high all night, or dip-then-rise? That pattern changed how I read my fasting number more than any single morning value.

18 lbs down while lifting is huge. Not a doc, just someone who over-logs. My fasting didn’t bump so much as get noisier: when I woke at 5:30 vs 7, the same body read 7–10 pts higher, and short sleep did the same. I started noting sleep duration, last bite, and evening lift days in my CGM app. My weekly CGM average tracked A1c better than any single fasting value. Have you looked at your overnight low and the 4–5am rise, or just the morning number? Also curious how your 70g protein feels with 3x lifting—mine needed a late snack to keep recovery decent, but that’s just my n=1.

My morning readings seem tied to lifting days more than weight. After 3x/wk lifting, next-morning was 7–10 pts higher, then dropped on rest days. I started tagging workout type in my log. Are you logging lifting vs rest days? Also, 62 vs 200 enrollment makes me want site count/phase before comparing those two trials.

My fasting did a weird bump around month 3: 94→103 while weight and waist were still dropping. Turned out I was sleeping 5.5 hrs, eating dinner at 9, and a little dehydrated. Once I moved dinner earlier and actually drank water, it drifted back to mid-90s over ~2 weeks. Sharp follow-up: have you had a cold, bad sleep stretch, or extra stress lately? Are you logging sleep alongside glucose? That’s the pattern I’d check first.

i’m 16 weeks in and my CGM showed a similar odd bump around weeks 12–14. What cracked it for me was logging sleep and “last bite” time next to fasting glucose. My highest mornings followed short sleep or a later, bigger dinner—not the weight trend itself. Are you tracking sleep or overnight lows? Mine sometimes dipped around 3am and then rebounded, which made the morning number look worse before it settled.

Honestly, road-warrior here, so my “fasting” number is really a hotel-sleep report. I tag CGM with bedtime, time zone, and whether I ate after 8pm. Pattern: red-eye or <6h sleep = fasting up 8–12 points; same dinner at home = back to my usual range. Weight kept dropping either way. Have you been logging sleep or travel days next to those 104s? Also curious whether the trial listings are just on your radar or you’re actually considering screening—no pressure, just nosy.

night shifter here. My “fasting” number is garbage unless I log time since last calories. 6am after a shift: 108. After 8h sleep, no snack: 92. Same week. I tag waking vs fasting in my app, plus sleep and shift length. The wake-time one was the scary one. What’s your gap between last meal and draw? Also A1c can lag. I’d watch waist and sleep before freaking out.

Honestly, i’ve been logging weekly averages alongside CGM, and the one pattern that surprised me was sleep and dinner timing, not lifting. On weeks when my average sleep dropped under 6.5 hours or dinner landed after 8 pm, my fasting average drifted up 7–10 points even though weight and waist were still moving down. Moving dinner earlier and adding a short after-dinner walk brought it back over about two weeks. Have you compared your fasting readings to sleep duration or last-meal time? Also, was your A1c from the same draw as the fasting glucose, or a separate earlier one? That timing can make the picture look stranger than it is.

I'm 12 weeks in and my fasting number is way more tied to sleep and late meals than weight. I log last bite time, sleep duration, and alcohol; a <6h night or eating within 2h of bed consistently bumps me 7–9 mg/dL, even while my waist is shrinking. In the trials, early fasting glucose is often noisy because dawn effect/hepatic output and stress hormones don't track linearly with fat loss. Did you track sleep or meal timing around that 96→104? Also, was the A1c from the same draw? Mine looked worse when I'd had a rough few weeks of poor sleep.

Plateau twin here. What shifted my fasting numbers wasn’t weight—it was sleep and late dinners. My ring showed nights under 6.5h pushed fasting to 100–108; 7.5h+ got me back to mid-90s with same food. I also moved my last meal 3 hours earlier and saw a gradual drop over two weeks. Weight is still stuck, so solidarity. Have you looked at sleep quality or how late you’re eating? That was my missing data point.

I’m n=1, but my fasting glucose tracked evening training load more than weight. Mornings after heavier lifts + a later dinner, it ran 5–8 mg/dL higher, while my overnight CGM mean and post-meal excursions were unchanged. In the trials, early fasting changes don’t always track A1c or mean glucose. Did you look at overnight mean/time-in-range vs just the fasting stick? That split stopped me from over-reading one number.