Saxenda week 14: 8.6 kg down, why no NCT03560336 efficacy data?

Post-marketing studies just report enrollment and safety. 758 is decent.

Week 12 flattening seems like a real pattern. 9 kg by week 16, then nothing for a solid month — and what broke the stall in my tracking was protein and walking, not the medication side.

A1c 5.4 and fasting 92 are solid. Same time each morning?

NCT03560336 is a regulatory rPMS, not a weight-loss efficacy trial. The RAW record only lists 758 enrolled. People treat it like a hidden Phase 3.

Opposite pattern in my tracking. Hunger came back but weight kept drifting down slowly. Around week 20 of logging is when clothes size changed, not the scale. Labs stayed stable though.

That 758 number is the only hard figure, right? No BMI change, no adverse event counts. Feels less like secrecy, more like a data dump requirement.

I wouldn't hang your expectations on the rPMS data. The bigger debate is the rodent thyroid tumor signal. The review I read looked at seven approved GLP-1 receptor agonists using six weight-of-evidence domains and two-year rat carcinogenicity bioassays. It concluded the rat tumors happen through a known human-irrelevant mechanism. That doesn't explain your week 14 plateau, but it does explain why the regulators aren't treating those findings as a human safety crisis. The 758-person rPMS record just isn't built to answer weight-loss curve questions. If anything, I'd want a real-world registry with serial weights, not a post-marketing safety report.

The thyroid thing gets blown up every few months. The review sounds more reassuring than the headlines. Did your clinician mention baseline thyroid labs beforehand, or is that just something people stumble into later during lab work and insurance paperwork?

Fifteen months in and the thing that finally explained my week-12 hunger comeback wasn't the scale, it was a tape measure: 96 cm waist in March, 84 now, while my weight sat dead flat for five straight weeks around month four. I was weighing daily and panicking over 0.3 kg swings that were pure sodium from Friday takeout, so I switched to once a week, same morning, same conditions, and that flat stretch turned out to be water hiding a 1.9 kg drop that laned all at once. My contrarian take is that week 12 usually isn't the medication tapping out, it's the point where the easy inflammation water is gone and loss starts costing you actual effort — mine restarted when I front-loaded 30 g of protein at breakfast and stopped eating after 7:30. What's your waist measurement done since week 8? Down 8.6 kg from 104, I'd bet you're down 8-10 cm even if the number stalls.

yo, mine went sideways around week 12 too. for me it wasn't the med suddenly quitting; it was habits drifting. i was logging in mfp and my protein fell from ~140g to like 95g while my step count tanked from 8k to 4k during a raid grind, plus i was chugging diet soda all night. swapped to fizzy water + a big yogurt bowl around 10pm and the 2am pantry stare got way less loud. not magic, just one variable. did anything shift for you at week 12—sleep, steps, protein, caffeine? also

I did the same ClinicalTrials API pull—NCT03560336’s results section is empty, just outcome measures, no participant flow or numbers. So there’s nothing to compare yet. On the hunger noise: my sheet tracks a 7-day hunger average and 14-day weight trend. When hunger spiked, my loss slope flattened about 10 days later, and the only leading variables were sleep and steps, not my food log. Did your log show a lag like that, or did hunger and scale move the same week?

Week 12 hunger comeback here too — solidarity.

Two things I’d poke at. Data side: check EudraCT/EU CTR—some rPMS results land there before CT.gov’s results section wakes up. Hunger side: at 95.6 your maintenance is roughly 200–300 kcal/day lower than at 104.2, so if intake stayed flat the deficit quietly shrank. Mine also coincided with steps dropping ~20%, per watch. Did your weekly steps, sleep, or protein average move around week 12? That’s usually my first place to look before assuming the med changed character.

late-night gamer here. my week 12 hunger noise lined up with soda-swap stuff: dropped diet soda, overdid coffee, sleep went 7.5 -> 5.5 on raid nights. started logging hunger 1-10 at midnight next to sleep/caffeine, and it tracked sleep way more than shot day. are you logging those beside weight? data side: does NCT03560336's posted protocol list weight change as primary, or something else? if primary is different, empty results tab might be less about efficacy and more about registry weirdness.

I also daily weigh and live on the trend line. My week-12 hunger noise spiked during a

Hi, total newbie here (day 3), so take this with salt. I’m using a food app and noticed my “hunger noise” is louder on mornings I skip protein and just have coffee. Have you checked your week 12 log for a protein or fiber dip? On NCT03560336, if the raw entry has no numerics, could it just be a placeholder until the results tab populates? And is 758 enrollment or completers? Sorry if those are silly first-week questions — I’m just trying to learn how to read these entries.