I’m 14 weeks into tirzepatide after about 9 months on semaglutide, and the appetite suppression is solid — down 38 lb, walking 8k steps most days. But the weird part is the flatness. Food noise is quieter, yet I’ve lost interest in my Sunday long runs and even my morning coffee feels like a chore. Not sad exactly, just muted.
I keep wondering if it’s class-specific. In the trials, mood/anhedonia wasn’t a headline effect, and I know low intake, poor sleep, and depression can all look like this. Still, it feels more like reward circuitry than just “eating less.” I’ve been trying to eat enough protein and sleep 7.5+ hours, which helped maybe 20%.
Has anyone switched from one GLP to another and had the anhedonia lift, stay the same, or get worse? Not looking for dosing advice, just lived experiences.