Did anyone else get flat mood on one GLP but not another?

Sep 30 2738 views 31 posts

I’m 14 weeks into tirzepatide after about 9 months on semaglutide, and the appetite suppression is solid — down 38 lb, walking 8k steps most days. But the weird part is the flatness. Food noise is quieter, yet I’ve lost interest in my Sunday long runs and even my morning coffee feels like a chore. Not sad exactly, just muted.

I keep wondering if it’s class-specific. In the trials, mood/anhedonia wasn’t a headline effect, and I know low intake, poor sleep, and depression can all look like this. Still, it feels more like reward circuitry than just “eating less.” I’ve been trying to eat enough protein and sleep 7.5+ hours, which helped maybe 20%.

Has anyone switched from one GLP to another and had the anhedonia lift, stay the same, or get worse? Not looking for dosing advice, just lived experiences.

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I’ve been on both classes too, and the flatness for me tracked less with the med and more with under-fueling + sleep debt. At goal/maintenance now, I still log mood 1–10 next to protein, water, steps, and sleep. When my Sunday run felt like a chore, I dropped pace/distance goals for two weeks and just did a favorite loop with a podcast — interest came back slowly. Might be worth checking:

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I’m a few years out and maintaining. I had a muted patch on the GLP that quieted food noise the hardest—interest in my usual long ride vanished for a bit. What helped was tracking three things in a notes app: sleep, protein/calories, and a 1–10 “did I actually enjoy this?” score for workouts. My flatness clustered on weeks I was under-eating and sleeping badly, not randomly. I also swapped the big workout for a short easy version with a friend, no pace goal, and the spark came back slowly. Not saying that’s your cause, but it’s a cheap pattern to check. Has yours been constant since the switch, or does it ease/rebound across the week?

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For what it's worth, Small-town gal here. I had a muted stretch on one of them and what cracked it for me was a dorky paper log: mood 1–5, sleep, water, and whether I got outside before noon. Mine was worst on low-sleep/high-coffee weeks, and coffee felt like a chore too. Adding a 10-minute sunny porch sit and a real lunch pulled me out of the gray. Have you tracked mood next to sleep/hydration? And did the flatness start right after the switch, or creep in when your long-run routine slipped?

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Not the same timeline, but I run a café, so I’m around pastries and espresso all day. My flatness ended up being partly under-eating at lunch—I’d nibble, skip real food, then the 3pm slump felt like a personality change. I started logging mood 1–10 next to protein, water, and whether I got outside. Weirdly, my Sunday run spark came back when I ate a proper breakfast instead of just coffee. Sharp question: does the muted feeling hit harder on days you don’t run, or is it pretty constant? If it’s constant, that’s a different puzzle than if it lifts after movement.

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Hi, I’m brand new here — literally week one, so I’m mostly lurking and nervous. This thread is exactly what I’ve been wondering about. Not asking for advice, just curious: did the flatness show up before or after your runs started feeling like a slog? I’ve been jotting down a tiny 1–5 mood score, sleep hours, and whether I got outside before noon. Only 6 days in, but my blah-est afternoon lined up with terrible sleep

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not a runner but i get the muted thing. mine showed up when i quit my nightly sda + 2am queue ritual cold turkey. i was tracking calories/steps but not “stuff i actually look forward to.” started a dumb note with a 1–5 want-to score for 3 things (game night, walk, fizzy water swap) and flat days were usually zero 4s. adding back one tiny anticipated thing helped more than forcing old hobbies. did yours go flat around when you changed any daily rituals besides the shot?

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Not the same med switch, but I had a similar flat patch and realized my “easy” runs were slower at the same effort while my sleep was 45 min shorter. My watch’s HRV also dipped for a few weeks. I started a Sunday note: mood 1–5, hunger, sleep, and whether I’

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One thing I didn’t expect: my flat patch came with losing the anticipation around things, not just food. I started a dumb 1–5 note in my phone for mood, sleep, and whether I’d eaten an actual lunch before 3pm. Turns out my worst days were long-run days where I’d had coffee + a few bites and then wondered why a 5-mile felt gray. Not saying it’s the same for you, but is your flatness worse on run days/morning-coffee days, or pretty steady? That pattern might tell you more than the scale.

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honestly dorm life here, so my “cooking” is a microwave and hope. The weirdest thing for me was that the flatness tracked less with the med switch and more with my breakfast shrinking to a sad granola bar. I started rating “do I actually want this coffee?” 1–5 in my notes app, plus whether I’d eaten 20g+ protein by 10am. Turns out my Sunday walk felt less gray on yogurt + peanut butter days. Not saying that’s your thing—but did your runs go flat before or after your portions dropped? That split might tell you something.

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I track a 1–10 “interest” score in my notes app next to sleep, steps, and outdoor light. My flat stretch lined up with sub-7h nights and gray mornings, not with appetite changes. Adding a 10-min daylight wak before my usual morning ritual helped a little

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fellow dorm-dweller here. My weird tracking discovery: I started rating mood 1–5 next to protein and steps in the same free spreadsheet, mostly because I’m a nerd with no social life. My flat weeks weren’t random — they lined up with days I lived on dining-hall pasta and coffee and forgot actual protein (cottage cheese cups, tuna packets, hard-boiled eggs from the cafeteria). Not saying that’s your thing, just n=1. Sharp question: when you skip the Sunday run, does the flatness get worse, or do you feel weirdly relieved? That difference might tell you if it’s lost reward vs. just fatigue.

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I’ve been here long enough to remember the “flat but not sad” threads. For me that muted patch lined up less with which med and more with under-fueling on workout days. I started a dumb 1–5 mood log next to whether I’d had a real breakfast and 10 mins of morning light before screens. My Sunday long-run itch came back when I stopped treating appetite suppression as a free pass to skip pre-run fuel. Have you tracked mood against run-day fuel/light, or only against the med switch?

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I track mood 1–10 and sleep hours in the same note as steps, and my flat patches almost always show up when sleep drops even if walking stays at 8k. Are you sleeping differently since the switch? For me, the runs didn’t feel bad physically—just no spark. What helped was keeping one tiny “anchor” ritual: Saturday night laying out clothes and a podcast

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I’m not a runner, but my flt patch showed up when my eating got chaotic—two kids, school run, I’d realize at 4pm I’d had coffee and half a crust. I started a snack drawer just for me (jerky, almonds, dried mango) and set a 3pm phone alarm. Tracking mood 1–5 next to my steps was eye-opening: my lowest days were almost always no-sit-down meals. Did your muted feeling come on gradually, or did it line up with a shift in your day? I’d look at meal rhythm before blaming the switch.

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Sounds more like anhedonia than depression. I track mood 0–10 daily with training load, sleep, and calories. My flat patch didn’t map to the med switch at all — it mapped to long-run days where appetite suppression hid underfueling. Once I logged it, Sunday motivation was the first thing to flatline. Do you have calorie/protein data over the same 14 weeks? If the flatness clusters after long runs or low-intake days, that’s a concrete pattern worth bringing to your prescriber.

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I’d bet the switch is getting too much credit. I track a 1–10 “interest” score for coffee, runs, music, texting friends, and mine went flat when my weekly carbs dropped ~90g and deep sleep fell, not when I changed meds. Trendline: interest 7→4 over three weeks, then 4→7 when I put a real pre-run breakfast and a standing Sunday coffee-with-a-friend back in. N=1, but it made me stop blaming the molecule alone. Have you logged interest scores against weekly carbs/sleep, or just weight and steps? The contrast might show whether it’s appetite suppression or underfueling.

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Honestly, i’ve only been on one, so not a direct comparison, but I track mood 1–5 next to sleep, protein, and steps. My

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Did your flatness line up with sleep or resting HR at all? The Sunday long-run apathy is what I’d key on. I had a similar flat stretch and started logging mood 1–10, sleep, protein, and run distance in a note. Mine correlated less with appetite and more with 2–3 nights of bad sleep plus low protein on run days. Coffee also stopped feeling rewarding. Have you looked at your last few weeks of wearable data or a simple mood log? Curious if the pattern is random or tied to recovery, because that changes what I’d look at next.

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not the same meds, but the coffee thing hit home. I thought I was “flat” when I was actually under-fueled and dehydrated on long-walk days. I started noting whether flat days followed a low-salt, low-carb dinner—9 times out of 10 they did. Adding a salty snack and a real breakfast before my Sunday walk didn’t fix everything, but my interest in my usual podcasts came back. Have you noticed if the muted feeling is worse after your longer runs, or is it pretty constant? That pattern might tell you whether it’s the deficit or something else.

Hi, I’m brand new here — only week one, so mostly lurking and taking notes. Something I’ve started tracking is “did I laugh today?” Not mood exactly, just whether anything actually felt funny. For me, flat shows up as no laughing first, before I’d even call it sad. Does yours feel more like losing interest in making new plans, or just old favorites like your run and coffee going gray? That part caught me because it’s a fear of mine too.

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I noticed something similar on one GLP but not the other. What helped me tease it apart was changing the context, not the dose: I swapped a solo long run for a slow social one and made coffee a porch thing with no phone. The desire didn’t come back first; the enjoyment did. In the trials, mood isn’t really the main endpoint, so it’s hard to know what’s the drug vs. a deficit vs. life. Does your flatness hit everything, or mostly solo/reward-y stuff like runs and coffee? If a 5-min favorite album or a walk with a friend still registers even a little, that seems useful.

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not a med switch thing for me, more a ritual thing. i had this whole post-gym wind-down — same playlist, same dumb youtube vid, big glass of whatever — and when i dropped it during a diet push my evenings went gray even thugh i wasn't sad. started jotting mood 1-5 next to steps in my

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The coffee chore hit home—mine went gry too. A new walking route gave me a tiny spark back.

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Not the same meds, same vibe though. My weird tell was that my beloved dorm microwave “pizza” (tortilla + mozz + tuna packet, don’t judge) stopped tasting like a Friday treat and started tasting like homework. I’d accidentally made every meal a protein-delivery system. So I added one dumb 2-minute non-food ritual before dinner: cheap iced tea from the vending machine and a trashy podcast. It didn’t magically fix the flatness, but it gave my brain a tiny anchor. Did your Sunday runs fade before or after the food noise got quieter?

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This matches the coffee thing for me. The flatness wasn’t sadness — everything just had the same emotional volume. What helped me spot it was a dumb two-week experiment: one “just because” thing daily that had nothing to do with weight. A sketch, a podcast walk, calling my sister. If I skipped it and genuinely didn’t care, that told me more than any score. Curious — did your long runs feel flat physically too, or was it mostly the anticipation/motivation that vanished? That distinction changed how I approached my own reboot.

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Daily weigher here too. The flatness hit me when I swapped meds, and my odd clue was resting heart rate — it dropped 4–5 bpm while steps stayed flat. I started a tiny “anti-flat” ritual: 10 min outside, no podcast, no pace, just weather. Also traded Sunday long run for a 2-mile coffee walk with a friend. Took about two weeks for coffee to taste like coffee again. Did your flatness start right after the switch, or after a whoosh/stall? That timing might tell you if it’s the med or just the deficit grind.

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yep, flat on one but not the othr here too. Coffee turned into a chore for me as well — it did lift eventually.

Had a flat/beige stretch too—kept my runs easy and waited it out. You’re not alone in the muted zone.

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cafe owner here, so I feel this in a weird way. My flat patches show up as zero interest in dreaming up new specials — I just make the same lemon loaf and call it a day. What snapped me out wasn’t forcing the run, but a standing Tuesday walk with my baker where we gossip the whole time. No pace, no watch. Did you notice if the muted feeling hit your creative/play side before it touched your runs? That’s my tell.

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One angle I haven’t seen mentioned: energy availability. When I was on one of these, I logged pre-run carbs, weekly loss rate, and post-long-run energy. My muted-coffee/run weeks lined up with my steepest deficits and sloppy fueling, not the med itself. The interest came back when I ate more around training, before my weight trend changed. Did your flatness start while you were still doing Sunday long runs, or only after you’d already dropped them? That timing might separate the med from plain under-fueling.