Growth hormone releasing hormone

Review of GHRH: a 44-residue peptide that specifically increases circulating GH across species and may promote long-term growth, with ~70% human-rat homology.

Abstract

Human growth hormone releasing hormone (GHRH) was originally extracted from two pancreatic tumours in patients with acromegaly, and is now known to consist of a 44 residue amidated peptide or its C-terminal-shortened derivatives.. The sequence of rat GHRH has also been determined; this 43 residue peptide shows approximately 70% homology with human GHRH, and is located mainly in the arcuate.

Key Findings

Exogenous GHRH specifically increases circulating GH in many species, and in the long term may increase growth.

Study Design

Animal study