Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency

Sermorelin (29-amino-acid GHRH analog) effectively stimulates GH secretion and serves as a rapid, specific diagnostic test for growth hormone deficiency in children.

Abstract

Sermorelin, a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH), is the shortest synthetic peptide with full biological activity of GHRH.. Intravenous and subcutaneous sermorelin specifically stimulate growth hormone secretion from the anterior pituitary.. Hormone responses to intravenous sermorelin 1 microg/kg bodyweight appear to be a rapid and relatively specific test for.

Key Findings

Hormone responses to intravenous sermorelin 1 microg/kg bodyweight appear to be a rapid and relatively specific test for the diagnosis of growth hormone deficiency. | False positive growth hormone responses are observed in fewer children without growth hormone deficiency after sermorelin than after other provocative tests. | Adult data indicate that the combination of intravenous sermorelin and arginine is a more specific test and this merits evaluation in children with gr

Study Design

Review article