Tesofensine week 6: weight down, resting HR up 18 bpm

The HR jump is the thing I'd watch. Over a five-week stretch mine went 61→73, then settled back to 68. Did sleep latency track with HR, or did it lag behind?

The lag is real though. HR ticks up first, insomnia about four days later, fasting glucose drops too. Spring allergies wreck my HRV worse than most supps.

Appetite rebound at week 4 is interesting. I had the same around day 26, then it leveled out. Are you logging protein and sodium? Water shifts hide a lot.

Sodium matters. Weight dropped 2 kg in three days after cutting carbs, then bounced 1.4 kg after salty meal. Glucose shift seems notable if it holds to week eight.

Not sure glucose change is drug-specific. Mine went 99→93 but I also started walking after meals. HR seems more consistent in my own tracking. Same time each morning?

Same-time measurement matters. My supine was 59, standing 72.

The pattern that keeps showing up in n=1 lifestyle logs — the ones people start in January and run for a couple months: fast HR/HRV shift in the first two weeks, then partial adaptation by week six. Common surprise: weight down 3.8 kg at week eight, but the waist drops more than the scale number would suggest, so water and glycogen are probably muddying the early readings. The week-four appetite rebound shows up in those logs too, and it tends to line up with worse sleep, not hunger. Worth knowing before you compare anything: if glucose stays lower after eight weeks without diet changes, that's more interesting than the first six. And the clearest signal in these logs is usually morning orthostatic HR, not scale weight.

Week 6 was my RHR peak too — 53 to 71 — but the plot twist was my HRV tanked for 10 days before the scale moved again, so I stopped blaming water/glycogen. Spring allergies only nudged me up 5-6 bpm; an 18 bpm jump is a different beast, at least in my log. What helped me separate things was a cheap orthostatic check: lying 5 min, standing at 1 min and 5 min, same time before coffee. My lying was 58, standing 1 min 86, 5 min 72; on allergy-season days alone it was 60/74/66, so the big standing spike lined up with the appetite-suppressant days, not pollen. The unexpected part: my sleep latency got better when I ate more of my carbs at dinner and stopped lifting after 7pm, even though RHR stayed high for another week and a half. Are you seeing the HR bump mostly overnight or in that first hour after you get up?

Waist down 5 cm on only 4.1 kg is the number I'd stare at, not the HR — in my own log the first 4 kg bought me about 2.5 cm and then it crawled, so either you're measuring the same spot at the navel fasted every time or you got a real visceral drop the scale is underselling. Against-the-grain note from my side: I quit obsessing over the resting number and started logging how long it takes me to fall asleep and whether I wake at 3am, and the latency moved a solid week before my HR did, which made me think the HR rise was mostly me sleeping worse rather than the other way round. The fix that actually worked was boring — last real meal about 2.5 hours earlier and no fluids after 8pm, wake-ups went from four a night to one and the morning number slid down over the following ten days. Quick question though: are you taking yours right on waking or after coffee? Mine reads 6-8 higher after caffeine and I spent three weeks comparing two completely different things.

My RHR did that too when sleep went sideways — solid reminder why I log morning values.

Look at overnight minimum HR, not just morning RHR. Mine went 54→72 on a similar run, but the sleep-window nadir only shifted 3 bpm. That localized the signal to fragmentation/early waking, not true sympathetic drive. Respiratory rate and

Tbh spring allergies are the seaky one for me. My RHR jumped 14 bpm one April and I blamed my diet, but it was the non-drowsy allergy tab I’d grabbed at the local pharmacy. Sleep latency went awful too. Are you taking anything seasonal like that, or did the sleep stuff start before the pollen hit? That HR/waist combo is still impressive, though.

Curious if you log HR recovery, not just resting. I do a fixed 20-step stair set and record HR at 60s post. My RHR was noisy, but recovery went 24→12 bpm during a similar six-week run, and that tracked ambient temp + my step count way better than the scale or BP. When recovery stayed flat, the high RHR was mostly noise; when it dropped too, I treated it as real load. Do you have a repeatable post-effort number? That’s the only thing that kept my trendline honest.

Spring allergies did that to me too—my RHR looked like I was jogging in my sleep.

Mine did that in April and I blamed the drug til I checked pollen, lol 😅

do you have overnight HR data, not just morning RHR? For me, morning RHR is basically a sleep-latency score: if I toss for 45 minutes, my morning number is up 8–10 bpm, but my overnight low barely moves. That distinction helped me stop blaming every scale bump on water/glycogen. Also, during those two appetite-rebound days, did your 7-day weight trend actually change or just the daily dots? My daily weights can jump 0.7–1 kg after bad sleep and a salty dinner while

I run a cafe, so I’m constantly tasting espresso and “quality checking” pastries, and my RHR is always higher on days I graze more and hydrate less. Have you logged caffeine timing against your RHR/sleep? Also, is your sleep latency more wired-heart or racing-brain? Mine feel totally different on my watch. Not saying it’s not the med, but spring chaos + cafe life can muddy the signal.

Night shit + pollen did my RHR dirty too. Morning numbers lie sometimes

oof, sleep latency is brutal. Does your overnight HR settle down once you finally crash?

Night shifter here. RHR + sleep latency together usually means I’m under-recovered and under-salted, not just the compound. Are you tracking HRV or waking temp? I did 3L water on nights and pissed out my electrolytes. Morning RHR was up 10, sleep was trash. Added a real meal with salt before shift

That sleep latency sounds rough; hope your overnight resting heart rate settles once you crash. 😴

Our little pharmacy has a free BP cuff by the door, so I check same time every week—my insurance won't cover fancy sleep tracking, so it's ring plus notebook for me. Curious if you track HRV or overnight respiratory rate? Mine does this weird thing where sleep latency spikes first, then HRV dips a day or two later, and RHR follows. Earlier last meal and a cooler bedroom moved it for me. Does your HRV drop before the RHR bump, or are they moving together?

Road warrior here—writing this from a hotel desk that’s two feet from the AC. My RHR spikes are almost always travel days: late airport dinner, tiny water intake, room too warm. I started doing grocery-store dinner (rotisserie chicken + bagged

Nice progress on the waist and fasting glucose. That HR bump would bug me too. One thing I’d add to your log: the gap between last meal and lights out, plus any alcohol. In my own tracking, a late dinner or even one drink pushed my overnight RHR up 8–10 bpm and made sleep latency awful, even while weight was dropping. Also, are you comparing RHR on hard-training days vs rest days? That split helped me tell “stimulant load” from plain under-recovery. Rooting for you—hope it settles.

curious how you’re capturing RHR — wearable overnight average, or a manual first-morning pulse? That split helped me: my overnight HR looked awful on nights I ate dinner late, but my true waking pulse barely moved. Did the appetite-rebound days

That RHR jump would have me side-eyeing my watch too — hope sleep settles so you can tell what’s what.

night shifter. My RHR is mostly a sleep-debt meter. Three ugly latency nights = +10–15 bpm, scale unchanged. Spring pollen does it too. Are you comparing work nights vs off nights? I log caffeine cutoff and last meal. If those drift, my resting HR is garbage data. Waist and fasting glucose moving is the real win. HR usually follows sleep, not the other way around.

Are you logging overnight HRV or just RHR? The +18 bpm with stable BP reads more sympathetic than volume to me. I’d overlay RHR with sleep latency, total sleep time, and wake-after-sleep-onset for 7–10 days; if it stays elevated on well-slept nights, that’s signal, not sleep debt. Late caffeine, alcohol, hard training, or a hot room can mimic this too. My tracker showed RHR +10 after late meals and poor cooling, then dropped 6 bpm once my sleep window was consistent. What’s your HRV trend doing?

Your glucose and waist trend look encouraging. One thing I track alongside weekly weight is overnight skin temperature and respiratory rate, because my spring allergies can raise both before I notice congestion; when pollen spikes, my sleep latency lengthens and my next-day morning HR is up 6–8 bpm even though BP is flat. Have you looked at any allergy/pollen or room-temperature variable in your weekly averages? It might help separate drug effect from seasonal noise.

For what it's worth, curious whether you’ve checked orthostatic vitals—stable seated BP can still hide a standing HR jump. My RHR spikes with dehydration/electrolytes show up way more on standing than sitting. Also, if your wearable logs respiration rate, that’s been a cleaner “actually stimulated vs just sleep-deprived” signal for me than RHR alone. What’s your overnight respiratory rate trend over the last two weeks?