Ipamorelin, the first selective growth hormone secretagogue

Ipamorelin identified as a potent pentapeptide GH secretagogue with high GH-releasing efficacy in vitro and in vivo, demonstrating selectivity for GH secretion.

Abstract

The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described.. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo.. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds lacking the central dipeptide Ala-Trp of growth.

Key Findings

A pharmacological profiling using GHRP and growth hormone-releasing hormone (GHRH) antagonists clearly demonstrated that ipamorelin,

Study Design

In vitro study