Research: KPV

Anti-inflammatory tripeptide — gut healing and immune modulation

KPV Research Papers & Clinical Studies

KPV is a peptide studied for its potential therapeutic effects. Anti-inflammatory tripeptide — gut healing and immune modulation This page indexes all published research papers, clinical trials, and scientific studies related to KPV that are available in the PepsReview research library. Each paper includes metadata such as journal name, publication year, citation count, study type, and a summary of key findings. Where available, we provide direct links to the original publication and DOI references.

Researchers can use this index to quickly locate evidence supporting specific KPV applications, compare study designs, and evaluate the strength of clinical evidence. Papers are sorted by relevance and citation count. There are currently 5 research papers indexed for KPV.

For vendor pricing, user reviews, and a complete peptide profile including mechanism of action, benefits, side effects, and regulatory status, visit the main KPV profile page.

KPV

Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides

J Pharmacol Exp Ther 2003 460 Animal Study

A structure-activity study dissecting which parts of alpha-MSH fragments carry anti-inflammatory signalling. Useful for understanding why KPV became a popular topical-research peptide and what the Lys-Pro-Val sequence actually does.

alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells

J Invest Dermatol 2004 440 Research Article

A review of alpha-MSH-derived fragments — including the KPV tripeptide — and their anti-inflammatory effects. Explains how a tiny C-terminal fragment keeps the parent hormone's anti-inflammatory activity while losing pigmentation effects.

Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore

Adv Exp Med Biol 2010 320 Research Article

A review of terminal anti-inflammatory signalling by alpha-MSH-derived peptides, with emphasis on how KPV-type sequences turn off cytokine cascades. Connects melanocortin research to practical anti-inflammatory peptide design.

Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin

J Pharm Sci 2017 180 Research Article

A delivery study testing transdermal iontophoresis of the KPV peptide. Relevant to research on getting peptides across skin barriers — the central technical challenge for topical peptide studies — and compares formulation approaches.

Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway

Tissue Cell 2025 20 Research Article

Airborne particulate matter (PM) poses a major environmental risk that impairs skin health by triggering oxidative stress, inflammation, and cell death.. In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT.