KPV
Anti-inflammatory tripeptide — gut healing and immune modulation
Overview
KPV is a tripeptide (Lys-Pro-Val) derived from alpha-MSH that has potent anti-inflammatory properties.
Key Information
Mechanism
Inhibits inflammatory pathways including NF-kB and IL-6, reducing systemic and local inflammation.
Benefits
- Potent anti-inflammatory
- Gut healing
- Immune modulation
- Multiple administration routes
Side Effects
- Minimal reported
Contraindications
- None established
Evidence Summary
Studies show efficacy in IBD, wound healing, and autoimmune conditions.
Research
Studies show efficacy in inflammatory bowel disease, wound healing, and autoimmune conditions.
View ResearchSafety
Well-tolerated. No significant adverse effects reported.
Frequently Asked Questions About KPV
What is KPV?
KPV is a research peptide also known as Lys-Pro-Val; Alpha-MSH(11-13). Anti-inflammatory tripeptide — gut healing and immune modulation It is studied for its potential therapeutic applications and is available from various research chemical vendors.
How does KPV work?
Inhibits inflammatory pathways including NF-kB and IL-6, reducing systemic and local inflammation.
What is the recommended dosage for KPV?
The commonly studied dosage range for KPV is 200-500 mcg daily. Dosage protocols vary based on research objectives. Always consult published studies and start with conservative amounts. KPV should only be used in controlled research settings.
Where can I buy KPV?
PepsReview indexes KPV pricing from multiple vendors. Check the Vendors tab above for a price comparison table showing cost per milligram, purity, COA status, and stock availability. Vendor reviews from real users are available on each vendor's profile page.
Is KPV legal?
US regulatory status: Research only. The legal status of KPV varies by jurisdiction. In most countries, it is sold as a research chemical, not for human consumption. Always verify the legal status in your country before purchasing.
What are the side effects of KPV?
Reported side effects include: Minimal reported. Always review safety data and published studies before use.
Key Research Papers on KPV
The following peer-reviewed studies and clinical trials are indexed in our research library for KPV. Each paper links to a detailed summary with key findings, study design, and publication metadata.
- Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides — J Pharmacol Exp Ther, 2003 (460 citations)
- alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells — J Invest Dermatol, 2004 (440 citations)
- Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore — Adv Exp Med Biol, 2010 (320 citations)
- Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin — J Pharm Sci, 2017 (180 citations)
- Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway — Tissue Cell, 2025 (20 citations)
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Write a Review
Rating Breakdown
Based on 2 reviews.
Reviews
KPV eliminated my chronic gut inflammation in 3 weeks. Stacked with BPC-157 for synergistic healing. The anti-inflammatory power is remarkable. Multiple administration routes make it versatile.
KPV is one of the most potent anti-inflammatory peptides. Used it for IBD symptoms - significant improvement. Can be taken orally which is convenient. Less research than BPC-157 but seems equally effective for inflammation.
Community Discussions on KPV
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