Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial
Authors: Jastreboff AM, Kaplan LM, Frías JP, Wu Q, Du Y, et al.
Journal
N Engl J Med
Year
2023
Citations
450
Type
Clinical Trial
Subject
Human
Condition
Obesity / Type 2 Diabetes
TL;DR
Phase 2 trial of retatrutide (GLP-1/GIP/glucagon triple agonist) in adults with obesity demonstrated dose-dependent weight loss and acceptable safety profile.
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DOI: 10.1056/NEJMoa2301972
Abstract
Retatrutide (LY3437943) is an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors.. Its dose-response relationships with respect to side effects, safety, and efficacy for the treatment of obesity are not known.. We conducted a phase 2, double-blind, randomized, placebo-controlled trial involving adults who had a body-mass index (BMI, the.