Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats
Authors: Kolik LG, Nadorova AV, Antipova TA, Kruglov SV, Kudrin VS, et al.
Selank (0.3 mg/kg) prevented ethanol-induced memory impairment in rats by regulating BDNF content in hippocampus and prefrontal cortex, showing neuroprotective effects.
Abstract
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving 10% ethanol as the only source of fluid for 30 weeks.. In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a.
Key Findings
The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures w... | In the object recognition test, Selank (0.3 mg/kg a day, 7 days, intraperitoneally) produced a cognitive-stimulating effect in 9 months rats not exposed to ethanol (p<0.05) and prevented the format... | In ex vivo experiments, Selank prevented ethanol-induced increase in BDNF content in the hippocampus and frontal cortex (p<0.05).Study Design
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About This Selank Peptide: Uses, Benefits & Safety Insights Research Paper
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Understanding Selank Peptide: Uses, Benefits & Safety Insights Research
Selank Peptide: Uses, Benefits & Safety Insights has been the subject of growing scientific interest, with researchers investigating its pharmacological properties, therapeutic potential, and safety profile across multiple study designs. The research landscape for Selank Peptide: Uses, Benefits & Safety Insights includes preclinical in vitro and animal model studies that elucidate its mechanism of action, Phase I clinical trials assessing safety and pharmacokinetics in human subjects, and larger Phase II and Phase III trials evaluating efficacy in target populations. Published studies vary in design — some are randomized controlled trials with placebo groups, others are open-label dose-escalation studies, and many are retrospective analyses of real-world data from clinics and compounding pharmacies.
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