Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

Heptapeptide Selank exhibits prolonged anti-anxiety and nootropic effects, with molecular mechanisms distinct from GABA-targeting anxiolytics, avoiding dependence issues.

Abstract

Anxiety and mood disorders are the most abundant mental health problems worldwide.. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor system activity.. As a rule, their use presents a wide spectrum of clinical issues such as dependence, memory impairment and etc.

Key Findings

There is an increasing appreciation of the role of neuropeptides and bioactive lipids in the pathophysiology of mood and anxiety disorders as "mild" agents. | Heptapeptide Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) exhibits prolonged anti-anxiety and nootropic effects. | In this issue, we tried to find the molecular mechanisms which may underlie Selank antianxiety effects.

Study Design

Research study